DETAILED NOTES ON LAUGHING GAS

The last proposed system of RBC vasodilation from the presence of nitrite is the reduction of nitrite to NO by Hb. Brooks very first studied the nitrite Hb conversation in 1937 and this do the job was later prolonged by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to form metHb and NO (Brooks, 1937; Doyle et